Human neutrophil phosphodiesterase

The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor.

PDE4B was previously shown to be a dominant PDE4 subtype of neutrophils. However, its physiological role in the neutrophil function has not been evaluated. In this study, the inhibitory effects of a phosphodiesterase 4B (PDE4B)- selective inhibitor (compound A) and subtype non-selective PDE4 inhibitors (roflumilast and cilomilast) were evaluated in human peripheral blood cells. Compound A, rofl...

Human neutrophil alloantigens systems.

Neutrophil alloantigens are involved in a variety of clinical conditions including immune neutropenias, transfusion-related acute lung injury (TRALI), refractoriness to granulocyte transfusions and febrile transfusion reactions. In the last decade, considerable progress has been made in the characterization of the implicated antigens. Currently, seven antigens are assigned to five human neutrop...

1566 Human Neutrophil

The capacity of humoral factors to influence polymorphonuelear leukocyte function has been recognized by in vitro studies. Neutrophil phagocytosis is enhanced by the presence of a fragment of the third component of complement, C3b, on a target cell or complex (1). Neutrophils respond chemotacticallv in vitro to by-products of the complement reaction sequence such as the cleavage product of the ...

Phosphodiesterase expression in human epithelial cells.

Epithelial cells play a critical role in airway inflammation and have the capacity to produce many inflammatory mediators, including bioactive lipids and proinflammatory cytokines. Intracellular levels of cAMP and cGMP are important in the control of inflammatory cell function. These cyclic nucleotides are inactivated via a family of phosphodiesterase (PDE) enzymes, providing a possible site fo...

Modulation of Human Neutrophil Apoptosis